P2 The dinoflagellate Alexandrium minutum activates mitophagy in cancer cells

P2 The dinoflagellate Alexandrium minutum activates mitophagy in cancer cells 

Christian Galasso1, Clementina Sansone1, Genoveffa Nuzzo2, Angelo Fontana2, Giovanna Romano1, Francesco Esposito1 and Adrianna Ianora1

1Integrative Marine Ecology, Stazione Zoologica Anton Dohrn, Naples, ITA
2ICB-CNR, Pozzuoli, ITA

Dinoflagellates are a diverse group of free living, symbiotic and also mixotrophic microalgae mostly known for the potent neurotoxins and other compounds having a diverse range of biological activities. In particular, those of genus Alexandrium produce many active compounds, such as some polyketides that have recently been discovered having anticancer activities. Here we focus on the biological activity of Alexandrium minutum, poorly explored for its biotechnological potential. Through a bioassay guided chemical fractionation of this species we isolated a glycopeptide, which is able to induce specific death signaling pathway in lung cancer cells without affecting normal cell viability. Our results demonstrated at molecular level that the glycopeptide from A. minutum activates mitophagic cell death pathway by the upregulation of Atg32, BNIP3L, PTEN- PINK1 genes.