P20 Actiskin: a new cosmeceutical formulation from the green microalga Tetraselmis suecica

P20 Actiskin: a new cosmeceutical formulation from the green microalga Tetraselmis suecica

Christian Galasso1, Clementina Sansone2, Angelo Fontana3, Genoveffa Nuzzo4, Adele Cutignano4, Tiziano Croci5, Rolando Lorenzetti5, Giovanna Romano6 and Adrianna Ianora2

1Integrative Marine Ecology, Stazione Zoologica Anton Dohrn, Naples, ITA
2Integrative Marine Ecology, Stazione Zoologica Anton Dohrn/Biosearch Srl, Naples, ITA
3ICB-CNR /Biosearch Srl, Pozzuoli, ITA
4ICB-CNR/Biosearch Srl, Pozzuoli, ITA
5Biosearch Srl, Milan, ITA
6Stazione Zoologica Anton Dohrn/Biosearch Srl, Naples, ITA

The present invention relates to the biological activity of an alcohol/water extract of the marine green microalga containing many active pigments and substances such as carotenoids having antioxidant, protective and repairing activity on human cells. Thus, the invention relates to the use of said extract in cosmetic compositions, neutraceutical supplements, medical compositions. Green microalgae contain many active pigments such as carotenoids having antioxidant and protective activity on human cells. This extract has a strong antioxidant and repairing activity in the human cell line (A549) reducing the expression of dehydrocholesterol reductase-24 (DHCR24) and prostaglandin reductase 1 (PTGR1) genes and proteins. The extract also reduces prostaglandin E2 (PGE2) levels in  cells damaged by H2O2 and has tissue repairing effects on human epidermal tissue model (EpiDermTM) indicating a potential cosmeceutical activity of this microalgal species.