P24 Exploring the Antibacterial and Anticancer Activity Potential of Five Marine Fungi

P24 Exploring the Antibacterial and Anticancer Activity Potential of Five Marine Fungi 

Hanne Bragmo1, Jeanette Hammer Andersen2, Espen Hansen2 and Teppo Rämä2

1NFH, Uit, Tromsø , NOR

2NFH, Uit, Tromsø, NOR

In this study, four marine fungal strains was fermented and tested for antibacterial and anticancer activity. The marine fungi were isolated from different habitats (seaweeds, driftwood and marine sponge). The objective was to try to find as many different bioactive metabolites as possible, by applying the OSMAC-approach (One Strain Many Compounds). Four different fermentation media were used, and in addition different incubation temperature, shaking as well as co-cultivation with marine bacteria was applied. Extracts were prepared using resin (Diaion HP-20, Supelco) and pure Methanol. In total 120 crude extracts were tested for antibacterial activity and anticancer activity.

The results from bioactivity testing of the marine fungi with various growth conditions will be presented.