P25 Cold adaptation - still hot for biotechnological industry?

P25 Cold adaptation - still hot for biotechnological industry?

Yvonne Piotrowski1, Netsanet G. Assefa1, Ronny Helland1 and Atle N. Larsen1

1Norstruct And Department Of Chemistry, Uit - The Arctic University Of Norway, Tromsø, NOR

For the last decade, the focus of our research has been on cold-adapted DNA-modifying enzymes. Compared to mesophilic enzymes these are in general more catalytically efficient and possess a lower thermal stability. The latter feature is of particular interest for biotechnological industry since it can lower the cost and time of a process significantly, but it is also a limiting factor as working with cold adapted enzymes is often challenging.

We have established methods to produce cold-adapted DNA-modifying enzymes in 1- to 10-l scale and to characterize them in detail. To date our innovation focused research and close collaboration with biotechnological industry have let to submission of five Disclosures of Invention to UiT, one patent has been filed and two license agreements with biotechnological industry have been signed. We believe that cold adapted enzymes clearly improve existing technologies but also enable the development of new ones.