P31 Microbial communities: isolation of antimicrobial compounds by an integrated omics approach

P31 Microbial communities: isolation of antimicrobial compounds by an integrated omics approach

Fortunato Palma Esposito1, Pietro Tedesco1, Emiliana Tortorella1, Maura Mirra1, Antonio Masino1, Angela Falco1 and Donatella De Pascale1

1Institute Of Protein Biochemistry, National Research Council, Naples, ITA

Microorganisms interact in different ways to benefit each other within a community. Potentially, their genome can encode for a huge amount of different and novel bioactive compounds, which could be exploited for pharmaceutical and biotechnological applications. The secret is to provide the right stimuli and conditions to microbes in order to induce changing in their metabolism. The application of a synergic approach, which includes the exploration of extreme environments (Poles, deep-sea), novel isolation techniques and co-cultivation experiments, could exponentially increase the chance to discover new bioactive molecules. Herein we report the isolation of several marine microorganisms able to produce antimicrobial compounds, by using an integrated omics approach. We forced the metabolism of the new strains in the co-culture conditions and applying OSMAC methodologies with the aim to increase the production of active molecules or inducing the expression of new metabolites and finally analysing the results by UPLC andHRMS.