P33 Isolation of bioactive compounds from Morocco marine cyanobacterial mats

P33 Isolation of bioactive compounds from Morocco marine cyanobacterial mats

Teresa Martins1, Vitor Ramos1, Maria Sofia Costa1, Lucinda Bessa2, Paulo Martins Da Costa2, Ralph Urbatzka1, Meryem Hassouani3, Sabour Brahim3, Vitor Vasconcelos4 and Pedro Leão1

1CIIMAR - Interdisciplinary Centre Of Marine And Environmental Research, Porto, PRT

2ICBAS - Biomedical Sciences Institute Of Abel Salazar, University Of Porto, Porto, PRT
3Faculty Of Sciences, Chouaib Doukkali University, El Jadida, MAR
4Faculty Of Sciences, University Of Porto, Porto, PRT

Cyanobacteria produce a large number of secondary metabolites with diverse structures and potent bioactivities. To explore this chemical diversity, biological material was collected in the coast of Morocco, from three marine cyanobacteria mats dominated by Lyngbya spp.

Using a bioactivity-guided isolation strategy, the mats were subject to extraction and fractionation. The resulting fractions were tested in different bioassays, namely antimicrobial, enzymatic inhibition and cytotoxicity against human cancer cells, which detect great bioactive potential.

One of the mats presented bioactivity in >50% of the obtained fractions, including higher antimicrobial activity against B. subtilis and S.aureus than commercial antibiotics such as tetracycline. In the anticancer active fractions, scytonemins were identified as the major component but it is unclear whether these are giving rise to the bioactivity. According to these promising results, future work will include the isolation and structural elucidation of the bioactive compound present in these samples.