1USR3151, CNRS, Roscoff, FRA
2 Griffith Institute For Drug Discovery, Griffith University, Brisbane, AUS
Oceans dominate the surface of our planet and they are the chest of a huge biodiversity, resulting from an adaptive evolution to many ecological niches. The aim of OCEANCHArCoT project is to explore the chemodiversity from marine organisms to find new chemical scaffolds able to inhibit cellular targets. Some protein kinases are implicated in cellular events leading to necroptosis. A disregulation of this pathway lead to neurodegenerative diseases, inflammatory diseases, viral and bacteria infections, allograft rejection, ischemia-reperfusion injury, brain injuries, atherosclerosis, Gaucher’s disease or in age-related macular degeneration. We apply bioactivity high-throughput screening and non-targeted metabolomics tools to prioritize the work on the best molecules. We tested 35 585 lead-like enhanced fractions representing 12 phyla, 23 classes, 440 genera. We obtained 102 hits from the primary screening. Currently, we focus on PAINS removal and dereplication of the best leads.