P48 Marine diatoms are a rich source of bioactivity

P48 Marine diatoms are a rich source of bioactivity

Richard A. Ingebrigtsen1, Espen Hansen2, Jeanette H. Andersen2, Gunilla Eriksen1 and Hans Christian Eilertsen1

1Norwegian College Of Fishery Science, Uit, Tromsø, NOR

2Marbio, Uit, Tromsø, NOR

Marine diatoms are a rich source of bioactivity. The very species-rich diatom group (Bacillariophyceae) are underrepresented in terms of reported bioactive marine compounds compared to e.g. marine bacteria, porifera, molluscs and seaweeds. Therefore, we aimed at investigating the potential of marine diatoms as a source of bioactive compounds with potential pharmaceutical or nutraceutical applications. 15 different diatom isolates were obtained from water samples in the Barents Sea. Mass cultivation was performed at the Phytoplankton lab at UiT. The biomass from the mass cultivations were freeze dried, extracted and prefractioned using HPLC and FLASH chromatography and all fractions were subsequently tested in the Marbio (UIT) assay line consisting of 23 different assays covering therapeutic areas such as anti - cancer, diabetes, immunoregulatory, anti-bacterial. In addition, the anti-oxidant potential was tested.