P5 Looking for antibiofilm agents from Polar marine bacteria: novel therapeutic solutions for biofilm-related nosocomial infections.

P5 Looking for antibiofilm agents from Polar marine bacteria: novel therapeutic solutions for biofilm-related nosocomial infections.

Annarita Ricciardelli1, Concetta Lauro1, Angela Casillo1, Marcello Ziaco1, Rosanna Papa2, Marco Tilotta2, Laura Selan2, Maria Michela Corsaro1, Maria Luisa Tutino1, Marco Artini2 and Ermenegilda Parrilli1

1Department Of Chemical Sciences, Federico II University, Naples, ITA
2Department Of Public Health And Infectious Diseases, Sapienza University, Rome, ITA

Hospital-acquired infections are among the major causes of death and increased morbidity among hospitalized patients. About the 65% of these nosocomial infections are biofilm related. The interest in the development of alternative anti-infective approaches for prevention and treatment of infections increased in recent years.
Cold-adapted marine bacteria represent an untapped reservoir of chemical-diversity able to synthesize a wide range of bioactive compounds, including antibiofilm molecules. The present research project aims to explore extreme marine environments and to exploit marine-derived biomolecules as a sustainable source of novel antibiofilm compounds. In this work, the antibiofilm activity of total organic extracts derived from cultures of Polar marine bacteria, belonging to Flavobacterium, Pseudoalteromonas, Pseudomonas, Psychrobacter and Psychromonas genera, were evaluated against some pathogenic bacteria, such as Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa. Suitable purification protocols will be developed to purify and characterize the most promising antibiofilm molecules, and their possible clinical applications will be investigated.