P9 Phytosterols in seaweed as nutraceutical for fighting Alzheimer’s disease

P9 Phytosterols in seaweed as nutraceutical for fighting Alzheimer’s disease

Michiel Michels1and Dorien Derksen2

1Research Group Biobased Products, Avans University Of Applied Sciences, Breda, NLD
2Research Group Biobased Products; Research Group Marine Biobased Specialities, Avans University Of Applied Sciences; HZ University Of Applied Sciences, Breda; Vlissingen, NLD

Oriental seaweed Sargassum fusiforme (Hijiki) can improve memory in an Alzheimer mouse model (Erasmus MC Rotterdam, University of Hasselt). This is probably due to phytosterols like 24(S)-saringosterol or its precursor fucosterol.

However, S. fusiforme has a high content of toxic inorganic arsenic. Therefore, European seaweed (or microalgae) could therefore be an alternative for the production of a nutraceutical containing phytosterols.

Analysis on Sargassum muticum from the North Sea shows presence of fucosterol. Future research includes the analysis of phytosterol content of other algae species and green extraction methods, which will be conducted to obtain a food-grade product containing the bioactive molecules.