New Approaches for Addressing Oceans' Dark Matters: Cultivability, Structure elucidation and Imaging

Friday March 10
Session 4: Applications of marine natural products
10:15

New Approaches for Addressing Oceans' Dark Matters: Cultivability, Structure elucidation and Imaging

Deniz Tasdemir, Professor
GEOMAR, Germany

Marine organisms are outstanding sources for potent and chemically diverse molecules. However, their development into medicine or other products is severely hampered due to supply/access issues and structural complexity for chemical synthesis. Most of the marine natural products (MNPs) have been reported from macroorganisms, but many MNPs have been suspected or demonstrated to have a microbial origin. Unfortunately, only about 1% of the estimated microbial diversity is cultivable, and many biosynthetic gene clusters within this 1% largely remain dormant in standard laboratory culture conditions. Hence, the vast majority of MNPs escape detection/annotation and their potential for discovery remain in total darkness. This presentation will describe our efforts to identify ‘new chemistry’ from both marine macroorganisms and microbes by employing innovative techniques such as OSMAC and co-culturing. Imaging Mass Spectrometry (IMS) methods will also be highlighted for visualization, localization and function of MNPs.